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Index > Protein center > LTBP4(Gene name) > Human
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  • LTBP4 (Gene name),
  • Latent-transforming growth factor beta-binding protein 4 (Protein name ),  LTBP4_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Gene name:
    LTBP4;
    Protein name:
    Latent-transforming growth factor beta-binding protein 4(LTBP-4);
    Alternative:

    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Forms part of the large latent transforming growth factor beta precursor complex; removal is essential for activation of complex. Interacts with LTBP1 and TGFB1. Binds to FBN1.
    Function:
    May be involved in the assembly, secretion and targeting of TGFB1 to sites at which it is stored and/or activated. May play critical roles in controlling and directing the activity of TGFB1. May have a structural role in the extra cellular matrix (ECM).
    Subcellular Location:
    Secreted extracellular space extracellular matrix
    Protein Attributes:
    Sequence length:
    1624
    Sequence:
    50:
    MPRPGTSGRR | PLLLVLLLPL | FAAATSAASP | SPSPSQVVEV | PGVPSRPASV | 
    100:
    AVCRCCPGQT | SRRSRCIRAF | CRVRSCQPKK | CAGPQRCLNP | VPAVPSPSPS | 
    150:
    VRKRQVSLNW | QPLTLQEARA | LLKRRRPRGP | GGRGLLRRRP | PQRAPAGKAP | 
    200:
    VLCPLICHNG | GVCVKPDRCL | CPPDFAGKFC | QLHSSGARPP | APAVPGLTRS | 
    250:
    VYTMPLANHR | DDEHGVASMV | SVHVEHPQEA | SVVVHQVERV | SGPWEEADAE | 
    300:
    AVARAEAAAR | AEAAAPYTVL | AQSAPREDGY | SDASGFGYCF | RELRGGECAS | 
    350:
    PLPGLRTQEV | CCRGAGLAWG | VHDCQLCSER | LGNSERVSAP | DGPCPTGFER | 
    400:
    VNGSCEDVDE | CATGGRCQHG | ECANTRGGYT | CVCPDGFLLD | SSRSSCISQH | 
    450:
    VISEAKGPCF | RVLRDGGCSL | PILRNITKQI | CCCSRVGKAW | GRGCQLCPPF | 
    500:
    GSEGFREICP | AGPGYHYSAS | DLRYNTRPLG | QEPPRVSLSQ | PRTLPATSRP | 
    550:
    SAGFLPTHRL | EPRPEPRPDP | RPGPELPLPS | IPAWTGPEIP | ESGPSSGMCQ | 
    600:
    RNPQVCGPGR | CISRPSGYTC | ACDSGFRLSP | QGTRCIDVDE | CRRVPPPCAP | 
    650:
    GRCENSPGSF | RCVCGPGFRA | GPRAAECLDV | DECHRVPPPC | DLGRCENTPG | 
    700:
    SFLCVCPAGY | QAAPHGASCQ | DVDECTQSPG | LCGRGACKNL | PGSFRCVCPA | 
    750:
    GFRGSACEED | VDECAQEPPP | CGPGRCDNTA | GSFHCACPAG | FRSRGPGAPC | 
    800:
    QDVDECARSP | PPCTYGRCEN | TEGSFQCVCP | MGFQPNTAGS | ECEDVDECEN | 
    850:
    HLACPGQECV | NSPGSFQCRT | CPSGHHLHRG | RCTDVDECSS | GAPPCGPHGH | 
    900:
    CTNTEGSFRC | SCAPGYRAPS | GRPGPCADVN | ECLEGDFCFP | HGECLNTDGS | 
    950:
    FACTCAPGYR | PGPRGASCLD | VDECSEEDLC | QSGICTNTDG | SFECICPPGH | 
    1000:
    RAGPDLASCL | DVDECRERGP | ALCGSQRCEN | SPGSYRCVRD | CDPGYHAGPE | 
    1050:
    GTCDDVDECQ | EYGPEICGAQ | RCENTPGSYR | CTPACDPGYQ | PTPGGGCQDV | 
    1100:
    DECRNRSFCG | AHAVCQNLPG | SFQCLCDQGY | EGARDGRHCV | DVNECETLQG | 
    1150:
    VCGAALCENV | EGSFLCVCPN | SPEEFDPMTG | RCVPPRTSAG | TFPGSQPQAP | 
    1200:
    ASPVLPARPP | PPPLPRRPST | PRQGPVGSGR | RECYFDTAAP | DACDNILARN | 
    1250:
    VTWQECCCTV | GEGWGSGCRI | QQCPGTETAE | YQSLCPHGRG | YLAPSGDLSL | 
    1300:
    RRDVDECQLF | RDQVCKSGVC | VNTAPGYSCY | CSNGYYYHTQ | RLECIDNDEC | 
    1350:
    ADEEPACEGG | RCVNTVGSYH | CTCEPPLVLD | GSQRRCVSNE | SQSLDDNLGV | 
    1400:
    CWQEVGADLV | CSHPRLDRQA | TYTECCCLYG | EAWGMDCALC | PAQDSDDFEA | 
    1450:
    LCNVLRPPAY | SPPRPGGFGL | PYEYGPDLGP | PYQGLPYGPE | LYPPPALPYD | 
    1500:
    PYPPPPGPFA | RREAPYGAPR | FDMPDFEDDG | GPYGESEAPA | PPGPGTRWPY | 
    1550:
    RSRDTRRSFP | EPEEPPEGGS | YAGSLAEPYE | ELEAEECGIL | DGCTNGRCVR | 
    1600:
    VPEGFTCRCF | DGYRLDMTRM | ACVDINECDE | AEAASPLCVN | ARCLNTDGSF | 
    1624:
    RCICRPGFAP | THQPHHCAPA | RPRA
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    Pfam:
    SMR:
    Pfam:
    String:
    UniGene:
    KEGG:
    MIM:
    Uniprot:
     
    FOR
    ELISA Kit for Human LTBP-4
    Cat.:
    E11075h
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    Packing:
    96T
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    ELISA Kit for Human LTBP-4
    Cat.:
    E11075m
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    MSDS:
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    Packing:
    96T
    CLIA Kit for Human LTBP-4
    Cat.:
    U11075h
    Price:
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    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human LTBP-4
    Cat.:
    U11075m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Polyclonal Antibody for Human LTBP-4
    Cat.:
    P11075Rb-h
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human LTBP-4
    Monoclonal Antibody for Human LTBP-4
    Monoclonal Antibody for Human LTBP-4
    Protein for Human LTBP-4
    Protein for Human LTBP-4

    R&D Technical Data
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    Precision
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    Recovery
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    Linearity
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    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
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    References
    1. 1.
      "Sequence and expression of a novel member (LTBP-4) of the family of latent transforming growth factor-beta binding proteins."
      Giltay R. , Kostka G. , Timpl R.
      FEBS Lett.411:164-168(1997) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3);TISSUE SPECIFICITY;VARIANT MET-1141
    2. 2.
      "Identification and characterization of a new latent transforming growth factor-beta-binding protein, LTBP-4."
      Saharinen J. , Taipale J. , Monni O. , Keski-Oja J.
      J. Biol. Chem.273:18459-18469(1998) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2);SUBCELLULAR LOCATION;ALTERNATIVE SPLICING;TISSUE SPECIFICITY;DEVELOPMENTAL STAGE;INTERACTION WITH LTBP1 AND TGFB1;VARIANTS ILE-194; ALA-787; ALA-820 AND MET-1141
      tissue: Heart.
    3. 3.
      "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
      Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4)
      tissue: Embryo.
    4. 4.
      "The DNA sequence and biology of human chromosome 19."
      Grimwood J. , Gordon L.A. , Olsen A.S. , Terry A. , Schmutz J. , Lamerdin J.E. , Hellsten U. , Goodstein D. , Couronne O. , Tran-Gyamfi M. , Aerts A. , Altherr M. , Ashworth L. , Bajorek E. , Black S. , Branscomb E. , Caenepeel S. , Carrano A.V. , more...
      Nature428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    5. 5.
      "Sequential deposition of latent TGF-beta binding proteins (LTBPs) during formation of the extracellular matrix in human lung fibroblasts."
      Koli K. , Hyytieainen M. , Ryynanen M.J. , Keski-Oja J.
      Exp. Cell Res.310:370-382(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUBCELLULAR LOCATION
    6. 6.
      "Mutations in LTBP4 cause a syndrome of impaired pulmonary, gastrointestinal, genitourinary, musculoskeletal, and dermal development."
      Urban Z. , Hucthagowder V. , Schuermann N. , Todorovic V. , Zilberberg L. , Choi J. , Sens C. , Brown C.W. , Clark R.D. , Holland K.E. , Marble M. , Sakai L.Y. , Dabovic B. , Rifkin D.B. , Davis E.C.
      Am. J. Hum. Genet.85:593-605(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT URDS GLY-311
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